The CVOT is not expected to report until well after the initial NDA
Nat Chem Biol 16(8):841849
They compared around 215,000 people with diabetes prescribed weekly injections of GLP-1 agonists to just over 1.2 million people who continued to receive their usual non-GLP-1 medicines to reduce blood sugar
Safety, Tolerability, and Who Should Consider This Dose A 40-unit maintenance dose is generally well-tolerated in individuals without contraindications, though gastrointestinal side effects (nausea, constipation, diarrhea) remain common, particularly during escalation
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